And the route of drug administration is considered as an important factor in the development of CIPN. Research reports that paclitaxel-induced mechanical allodynia is due to the transcriptional increase in matrix metalloproteinases (MMP) 2 and 9 and decrease of metallopeptidase inhibitor 1 (TIMP1). 16% for FOLFOX.) Besides, CIPN apparently increases the financial burden on patients as well as the annual costs of healthcare. 6-month treatment of CapeOX or FOLFOX.(3% vs. found that high-grade CIPN (grades 3-4) was more likely to occur in 3-month treatment vs. Those side effects can result in a dose reduction of chemotherapy regime, even terminating the course of treatment, thus limiting therapeutic efficacy. ![]() ![]() Pain CIPN can be extremely disabling, with a marked impact on quality of life, functional ability, and risks of noncompliance with cancer treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is an inevitable dose-limiting side effect and approximately 30–40% of patients treated with neurotoxic chemotherapy agents, such as platinum, vinca alkaloids, and taxanes, will suffer from it.
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